Protein Details: Neuronal acetylcholine receptor subunit beta-3

Protein ID

ICDB_Pro_0763

Protein Name

Neuronal acetylcholine receptor subunit beta-3

Gene Name

CHRNB3

Organism

Homo sapiens (Human)

Length

458 amino acids

AlphaFoldDB

AF-Q05901-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Sequence

MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH

PDB Structures

8A5U

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Pericytoma With T(7;12) and Primary Thrombocytopenia

Location

DOI ID

10.1016/0888-7543(95)80228-e; 10.1016/j.celrep.2020.108025

RefSeq

NP_031416.3